SELF ASSESSMENT QUIZ: INFLAMMATION AND REPAIR

 

1. Which of the following are types of extravascular fluid accumulation that have a high protein concentration (choose one or more than one answer):
edema
 transudate
 exudate
 pus (purulent exudate)

2. Which pattern of permeability response is associated with direct damage to endothelium and involvement of all levels of the microcirculation (venules, capillaries, and arterioles)?

immediate transient response
 delayed sustained response
 immediate sustained response
 delayed prolonged response

 

3. Which pattern of permeability response begins in 1-10 minutes and is mediated by mediators including histamine, bradykinin, leukotrienes?
immediate transient response
 delayed sustained response
 immediate sustained response
 delayed prolonged response

4. Which endothelial molecule, expressed from Weibel-Palade bodies, is responsible for early leukocyte rolling during the inflammatory reaction?

 

5. Which of the following represents an oxygen-dependent bactericidal mechanism?
myeloperoxidase-halide system
 lysozymes
 major basic protein
 decreased pH secondary to lactate inhibition of bacterial growth

 

6. By either activation of Hageman factor (intrinsic pathway of clotting cascade) or tissue damage (extrinsic pathway of clotting cascade), the endproduct of the cascade is:
release of eosinophil chemotactic factor A (ECF-A)
 activation of myeloperoxidase-halide system
 elicit production of defensins
 creation of cross-linked fibrin

 

7. Which of the following are the MOST LIKELY mediators of chemotaxis and leukocyte activation in acute inflammation? Choose one or more answers.
leukotriene B4
 C5a
 bradykinin
 platelet activating factor
 interleukin-1 (IL-1)
 interleukin-8 (IL-8)

 

8. Which of the following is NOT TRUE of fever?
(Click here to see flowchart of fever pathway)
It is provoked by excessive interleukin-8 (IL-8) release
 It ultimately results from reduced heat dissipation from the skin
 It is prostaglandin-mediated
 Tumor necrosis factor may be a chemical mediator

9. What is the term used to describe an acute inflammatory process associated with a surface defect?