|
Image |
Slide # |
Tissue |
Mag |
Feature |
|
|
Case 14 |
Foreign body granuloma |
Gross |
Firm nodule, flesh colored or erythematous. |
|
|
Case 14 |
Foreign body granuloma |
LP |
Multinucleated giant cell within a nodular aggregate of histiocytes. |
|
|
Case 14 |
Foreign body granuloma |
Polarized |
Suture viewed with polarized light. |
|
|
Case 15 |
Hemangioma |
Gross |
Red/purple nodules and papules. May blanch with compression. |
|
|
Case 15 |
Hemangioma |
LP |
Proliferation and dilatation of blood vessels. Note RBCs in vascular lumina. |
|
|
Case 16 |
Pyogenic granuloma |
Gross |
Eroded or crusted "juicy" red nodule, often pedunculated. |
|
|
Case 16 |
Pyogenic granuloma
|
LP |
Superfical dark pink crust. Underlying granulation tissue comprising pale stroma. |
|
|
Case 16 |
Pyogenic granuloma |
HP |
Granulation tissue composed of capillary proliferation and edematous, pale stroma. Intermixed neutrophils and mononuclear cells. |
|
|
Case 17 |
Lipoma |
Gross |
Protruding lobule of adipose tissue from incision site. |
|
|
Case 17 |
Lipoma |
LP |
Mature adipose tissue with thin capsule. |
|
|
Case 18 |
Eczema |
Gross |
Ill-defined scaling and erythema. |
|
|
Case 18 |
Eczema |
HP |
Spongiosis (intercellular edema between keratinocytes in epidermis), and scattered lymphocytes in dermis |
|
|
Case 19 |
Psoriasis |
Gross |
Papulosquamous (scaly and erythematous and significantly raised above the skin) plaques. Thick silvery scale. |
|
|
Case 19 |
Psoriasis |
MP |
Parakeratosis (nuclei in stratum corneum), hyperkeratosis (thickened stratum corneum) and acanthosis (thickened spinous layer) |
|
|
Case 19 |
Psoriasis |
HP |
Same as above with neutrophils in stratum corneum. |
|
|
Case 20 |
Lichen planus |
Gross |
Papulosquamous plaques without silvery scale. 3 P's of lichen planus: purplish, papulosquamous, and polygonal). |
|
|
Case 20 |
Lichen planus |
MP |
Acanthosis, saw-toothed rete ridges, liquefaction degeneration in basal layer, and band-like lymphocytic infiltrate in upper dermis. |
|
|
Case 21 |
Verruca vulgaris |
Gross |
Flesh-colored, verrucous papule |
|
|
Case 21 |
Verruca vulgaris |
LP |
Hyperkeratosis, acanthotic spinous layer, prominent granular layer and koilocytes (dark nuclei with perinulcear halos). |
|
|
Case 21 |
Verruca vulgaris |
HP |
Acanthotic spinous layer, koilocytes, and prominent granular layer. |
|
|
Case 22 |
Molluscum contagiosum |
Gross |
White umbilicated papule located usually on genital areas or face. |
|
|
Case 22 |
Molluscum contagiosum |
LP |
Prominent keratohyaline granules and molluscum bodies (dark pink intraepidermal bodies) in cystic ingrowth of thickened epidermis. |
|
|
Case 23 |
Herpes simplex |
Gross |
Grouped vesicles on an erythematous base. May crust and ulcerate. |
|
|
Case 23 |
Herpes simplex
|
HP |
Multinucleate epithelial cells along intraepidermal vesicle. |
|
|
Case 24 |
Pemphigus |
Gross |
Vesicles which may ulcerate and crust, found on trunk, extremities and mouth. |
|
|
Case 24 |
Pemphigus |
HP |
Intraepidermal vesicle with "tombstone" row of basal cells. Eosinophils and acantholytic keratinocytes contained within vesicle. |
|
|
Case 24 |
Pemphigus |
HP |
Immunofluorescent stains IgG or complement in a net-like pattern between epithelial cells. |
|
|
Case 25 |
Pemphigoid |
Gross |
Large tense bullae with thick blister roof. |
|
|
Case 25 |
Pemphigoid |
HP |
Subepidermal vesicle. |
|
|
Case 25 |
Pemphigoid |
HP |
Immunoflourescent biopsy stain for IgG and complement exhibits a linear pattern along the dermal/epidermal junction. |
