Pathology Review Carousel 11
Pathology Review Carousel 11
Neuropathology II, Part 2
Image
 Slide # Tissue Mag Feature
41 Base of brain Gross Contrecoup contusions of the orbital surfaces of the frontal lobes and the lateral and inferior surfaces of the temporal lobes. (Contrecoup contusions occur at pointn opposite to point of contact from sudden deceleration).
42 Cerebrum Gross Contusion (old). Note loss of the crest of the gyrus. (Coup contusions result from blow to stationary head, or a point of impact).
43 Cerebrum Gross Contusion. Note loss of the crests of two adjacent gyri with relative sparing of the base of the sulci.
44 Cerebral cortex LP Contusion. Note interruption of the molecular layer which is often spared in an infarct.
46 Brain and Dura Gross Subdural hematoma (blood between dura and leptomeninges). Brain and dura have been removed from skull. Clotted blood is beneath the dura (dense white curved line) in the subdural space (Resulted from bleeding from torn bridging veins.) Note compression of the cortex.
47 Brain and Dura Gross Subdural hematoma. Dura has been folded back to reveal clotted blood in subdural space.
48 Brain Gross Subarachnoid hemorrhage. Image missing.
49 Brain Gross Same. Often caused by vascular malformations or blood dyscrasias.
51 Circle of Willis Gross "Berry" or saccular aneurysm, posterior cerebral artery.
52 Circle of Willis Gross Ruptured saccular or berry aneurysm, anterior cerebral artery.
53 Cerebrum Gross Ruptured aneurysm with hemorrhage into brain parenchyma.
54 Brain Gross Ruptured aneurysm with subarachnoid hemorrhage.
55 Saccular aneurysm LP Elastic stain to show defect in wall of "berry" or saccular aneurysm.
57 Cerebrum Gross Hypertensive hemorrhage into hemispheric white matter.
58 Cerebellum Gross Hypertensive hemorrhage into pons with pons rupture into IVth ventricle.
59 Cerebrum Gross Hypertensive hemorrhage into basal ganglia region (specifically: internal capsule).
60 Cerebrum Gross Hypertensive hemorrhage into basal ganglia with rupture into lateral ventricles.
62 Brain of neonate Gross Germinal matrix hemorrhage.
63 Brain of neonate Gross Same, with intraventricular hemorrhage.
64 Brain, neonate Gross Intraventricular hemorrhage extension through foramina into subarachnoid space.
65 Skeletal M. (slide 165) LP Polymyositis. Note disruption of muscle fibes and the scattered inflammatory cells in the interstitium.
66 Skeletal M. MP Polymyositis. Degenerated skeletal muscle fibers (amorphous pink) with infiltrating macrophages and regenerating fibers with multiple nuclei and more lavender cytoplasm.
67 Skeletal m. MP Same. Also present are interstitial mononuclear inflammatory cells (small round blue nuclei).
68 Skeletal M. HP Polymyositis. Closer view of mononuclear inflammatory cells with lymphocytes, plasma cells and macrophages. Few eosinophils are also present.
71 Brain HP Krabbe's disease (globoid body leukodystrophy). A form of leukodystrophy which are dysmyelinating diseases resulting from either abnormal formation or catabolism of myelin. In Krabbe's disease deficiency of B-galactosidase results in accumulation of galactocerebrosides (curvilinear tubules).
72 Brain Gross Huntington's Disease (and Normal brain). a type of subcortical degenerative disease. Severe atrophy of the caudate and putamen. Compare to normal brain.
73 Midbrain Gross Parkinson's Disease. A type of subcortical degenerative disease. Note depigmentation of substantia nigra and to lesser extent of the locus ceruleus. Unknown etiology.
74 Midbrain HP Lewy body in Parkinson's Disease. Eosinophilic, intracytoplasmic spherical or vermiform inclusion often found in pigmented neurons, characteristic of Parkinson's.
75 Cauda equina Gross Amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease. Degeneration of motor neurons in the spinal cord and brainstem results in degeneration of pyramidal tracts and severe atrophy of anterior spinal roots which is demostrated here.
76 Brain Gross Pick's disease. A type of dementia. Severe atrophy of frontal and temporal lobes.
77 Brain HP Pick bodies (silver stain). Argyrophilic cytoplasmic inclusions (not specific).
78 Brain Gross Multiple sclerosis. A type of demyelinating disease of the CNS. Example of a plaque or area of demyelination found throughout the white matter.