| Image |
Slide # |
Tissue |
Mag |
Feature |
 |
1 |
Prostate |
Gross |
Nodular hyperplasia. Note bulging nodules of the periurethral
area (central or transitional zone) compressing the slit-like urethra.
Note also the compressed peripheral zone. |
 |
2 |
Prostate |
LP |
Nodular hyperplasia. Note the single nodule composed
of proliferating glands (and small amount of stroma) with some compression
of the adjacent surrounding prostate glands and stroma. |
 |
3 |
Prostate |
MP |
Nodular hyperplasia showing proliferating glands and
some compressed glands at the periphery. |
 |
4 |
Prostate |
HP |
Higher magnification of glands from a case of nodular
hyperplasia to show benign appearance (no nuclear enlargement, no prominent
nucleoli and some foci with 2 cell layers). |
 |
5 |
Prostate |
LP |
Nodular hyperplasia. Nodule of proliferating benign
glands. |
 |
6 |
Prostate |
HP |
Benign gland with two cell layers. (Absence of two
cell layers does not prove malignancy, but thepresence of two cell layers
is a good indication of a gland's benign nature). |
 |
7 |
Testis |
Gross |
Embryonal carcinoma. Note extensive hemorrhage (black
areas) and necrosis (yellowish tan foci). (This appearance is not specific
for embryonal carcinoma but could be found in most of the malignant, non-seminomatous
germ cell tumors). |
 |
8 |
Testis |
LP |
Embryonal carcinoma. Note benign seminiferous tubules
and the areas of tumor which at low power appears as nodules of closely
spaced cells with clear slits. Areas of hemorrhage and necrosis appear
as the more red area. |
 |
9 |
Testis |
MP |
Embryonal carcinoma. Nodule of tumor surrounded by
benign seminiferous tubules. |
 |
10 |
Testis |
MP |
Same. |
 |
11 |
Testis |
MP |
Embryonal carcinoma. Note glandular, alveolar, and
tubular areas. |
 |
12 |
Testis |
HP |
Embryonal carcinoma. Note indistinct cell borders,
large nuclei, some with hyperchromasia, and prominent nucleoli. |
 |
13 |
Testis |
LP |
Testicular infarct. Note hemorrhage and eosinophilia
of the seminiferous tubules. |
 |
14 |
Testis |
MP |
Testicular infarct. Note the eosinophilia of seminiferous
tubular cells with loss of some nuclei (coagulation necrosis). (Remaining
nuclei are pyknotic [shrunken and dark], or karyolytic [pale or faded],
changes that occur prior to nuclear loss in necrosis.) |
 |
15 |
Prostate |
Gross |
Prostatic adenocarcinoma. Landmarks for orientation
are not clear. However, the irregular whitish-tan focus of carcinoma is
peripheral and most likely posterior. Note the needle biopsy tract. |
 |
16 |
Prostate |
Gross |
Prostatic carcinoma and nodular hyperplasia. Note
the circumscribed nodules in the periurethral zone compressing the urethra.
Note the poorly defined, white, infiltrative carcinoma in the periphery
(posterior) of the prostate. |
 |
17 |
Vertebra |
Gross |
Metastatic prostatic carcinoma. Note the osteoblastic
appearance (looks like increased bone) and also disruption of one disc. |
 |
18 |
Prostate |
LP |
Prostatic adenocarcinoma. Note the haphazardly infiltrating
glands. Note the extension between the few large benign glands at the periphery. |
 |
19 |
Prostate |
MP |
Same |
 |
20 |
Prostate |
HP |
Prostatic adenocarcinoma. The glands are lined by
a single layer of cells containing large nuclei and prominent nucleoli.
Compare to the cells of the residual large benign gland at one corner of
the slide. (Two cell layers may not be easily identified in the benign
gland, butthe nuclei are small and there are no prominent nucleoli.) |
 |
21 |
Testis |
Gross |
Seminoma. Bulging gray or tan-white tumor with focal
congestion and hemorrhage, but no evidence of necrosis. |
 |
22 |
Testis |
LP |
Seminoma. Note characteristic separation of tumor
into nests by thin septa. |
 |
23 |
Testis |
MP |
Seminoma. Nests of large cells with clear cytoplasm
separated into nests by thin septa containing lymphocytes. |
 |
24 |
Testis |
HP |
Seminoma. Same as 23. Also note that many tumor cells
have distinct cell membranes. |
 |
25 |
Testis |
HP |
Same as 24. |