Pathology Review Carousel
Pathology Review Carousel
Infectious Disease

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Image
 Slide # Tissue Mag Feature
1 Case 1, slide 14 LP Lung with interstitial pneumonia. Note wide alveolar septa and hyaline membranes.
2 Case 1, slide 14 LP Lung with interstitial pneumonia. Note more cells appear to be in the alveoli because of sloughing of alveolar epithelial cells. (Need higher magnification to confirm cell types.)
3 Case 1, slide 14 HP Interstitial pneumonia. Note hyperplastic type II pneumocytes, wide alveolar septa, and only few alveolar spaces contain some macrophages.
4 Case 1, slide 14 HP Interstitial pneumonia. Note widened alveolar septa, with slight mononuclear inflammatory infiltrate and edema. Some macrophages and alveolar epithelial lining cells are in the lumen.
5 Case 1, slide 14 HP Alveolar space with some macrophages and sloughed epithelial lining cells. Note cells with viral inclusions: Purple intranuclear inclusions with halos, and one cell has small reddish-purple intracytoplasmic inclusions are very suggestive of cytomegalovirus (CMV).
7 Aorta Gross Note rough pitted ascending aorta (tree bark appearance) characteristic of syphilitic aortitis
8 Aorta Gross Severely atherosclerotic ascending aorta with saccular aneurysm. Note the descending aorta is not as severely affected with atherosclerosis.
9 Heart Gross Cardiac dilatation. Note roughness of first portion of aorta characteristic of syphilitic aortitis which weakens the wall and results in ectasia of the aortic root causing aortic insufficiency. Also note that the coronary ostia are narrowed from the changes.
10 Spinal cord LP Cross section of spinal cord showing Wallerian degeneration of the dorsal or posterior columns that is seen in Tabes dorsalis (a form of neurosyphilis).
11 Brain Gross Cerebral atrophy, most prominent in frontal lobes seen in general paresis (a form of neurosyphilis).
12 Penis Gross Chancre, single, painless ulcer with raised border (characteristic lesion of primary syphilis)
13 Hand Gross Cutaneous lesions of secondary syphilis, (generalized over the entire body including palms, soles and oral cavity)
15 Case 3 LP Spinal cord (some slides were of cerebral cortex) with nerve roots surrounded by inflammatory cells in the meninges
16 Case 3 LP Same
17 Case 3 HP Suppurative meningitis: meninges with suppurative inflammatory cells (many neutrophils).
18 Case 3 HP Bacterial meningitis: in addition to the suppurative inflammation, bacteria can be seen in the H and E sections (Need gram stain to tell if gram positive or negative)
19 Case 3 Very HP Small gram negative rods (coccobacillary forms) consistent with Hemophilus
20 Brain Gross Purulent meningitis (consistent with bacterial meningitis)
22 Case 4 LP Caseous necrosis surrounded by granulomatous inflammation
23 Case 4 MP Granulomatous inflammation with macrophages, some of which are epithelioid histiocytes, giant cells and lymphocytes. Also note caseous necrosis
24 Case 4 HP Granulomatous inflammation with giant cells and macrophages shown in this view
25 Case 4 Very HP Acid fast stain (AFB): numerous beaded acid fast organisms indicating myocobacterium. Culture would be needed to determine type of mycobacterium.
28 Case 5 LP Lung with patchy infiltrate in alveolar spaces
29 Case 5 HP Alveolar space filled with neutrophils and edema (suppurative inflammation)
30 Case 5 HP Degenerating skeletal muscle in alveolar space indicating aspiration
31 Case 5 HP Gram stain showing mixed bacteria with gram positive cocci and gram negative rods consistent with an aspiration of oral flora
33 Case 7 MP Lung with eosinophilic frothy material (pneumocystis carinii organisms and protein) in alveolar spaces. Alveolar septa are thickened with some mononuclear inflammatory cells and edema.
34 Case 6 HP Lung with GMS (silver stain) showing cysts of pneumocystis carinii. Note crushed ping pong ball or cup shaped appearance and the presence of central dots in some organisms. (Histoplasma capsulatum would not be compressed and would be found in granulomatous inflammation, not associated with eosinophilic frothy material)
36 Granulomatous inflammation HP Granulomatous inflammation with histiocytes and lymphocytes occurring with histoplasmosis (organisms are inconspicuous)
37 Liver HP GMS (silver stain) showing oval black-staining histoplasma organisms (the diffuse black areas are liver cells which are staining nonspecifically).
39 Coccidioides HP Spherules or sporangia of coccidioides immitis with neutrophils and macrophages.
40 Same Very HP Spherules or sporangia containing endospores
42 Cryptococcosis HP Round to oval organisms surrounded by clear halo
43 Same HP Mucicarmine stain of cryptococcus organisms showing mucicarmine positive capsules
45 Brain Gross Aspergillosis of the brain, note rounded foci of necrosis and hemorrhage. (Mucor is another fungus which causes hemorrhage and necrosis because of tendency for vascular invasion).
46 Liver LP Hyphae invading blood vessels
47 Aspergillus HP Narrow, septated hyphae with dichotomous branching (branching at 45 angle)
49 Brain Gross Hemorrhagic necrosis involving gray and white matter Mucormycosis.
50 Mucormycosis HP Inflammation containing the broad, nonseptate hyphae with 90 degree branching and hollow appearance of mucor.
51 Mucormycosis Gross Mucormycosis of the nasal sinuses in a diabetic
53 Candida HP Yeast and pseudohyphae (with GMS stain)
54 Mouth Gross Thrush
56 Herpes HP Two multinucleated cells with molded nuclei and intranuclear inclusions surrounded by halo consistent with Herpes simplex 1 or 2, or varicella zoster viruses
57 Herpes HP Two multinucleated cells with molded nuclei with clearing of the central nuclear chromatin and condensation of the chromatin at the periphery of the nuclei consistent with Herpes simplex 1 or 2 or varicella zoster viruses.
59 Arm Gross Petechiae of Rocky Mountain spotted fever
61 Uterus with one adnexa Gross Result of pelvic inflammatory disease.