Image
|
Slide # |
Tissue |
Mag |
Feature |
 |
1 |
Case 1 |
Micro |
Multiple myeloma, mediium power of bone marrow tissue section showing sheets of plamsa. |
 |
2 |
Case 1 |
Micro |
Multiple myeloma, high power showing sheets of plasma cells. |
 |
3 |
Case 2 |
Micro |
Acute myelogenous leukemia, low power of bone marrow aspirate showing monomorphic population of cells. |
 |
4 |
Case 2 |
Micro |
AML, high power of bone marrow aspirate showing several blasts with large nuclei and prominent nucleoli and cytoplasmic Auer rods. One blast is in mitosis. |
 |
5 |
Case 3 |
Micro |
Hairy Cell Leukemia, high power of peripheral blood smear showing a small normal lymphocyte and a "hairy cell" with finger nuclear chromatin, slightly larger nucleus and very lightstaining cytoplasm with fine cytoplasmic projections. |
 |
6 |
Case 3 |
Micro |
Hairy Cell Leukemia, another hairy cell next to a small lymphocyte. |
 |
7 |
Case 4 |
Micro |
Hodgkin's Disease (Nodular sclerosis type), low power of mediastinal mass showing bands of fibrous connective tissue subdividing the mass into nodules. |
 |
8 |
Case 4 |
Micro |
Hodgkin's Disease (Nodular sclerosis type), medium power showing lacunar cells, cells with clear space around the nucleus formed by retraction of the cytoplasm, which are associated with the nodular sclerosis type of hodgkin's disease. |
 |
9 |
Case 4 |
Micro |
Hodgkin's Disease, high power showing typical Reed-Sternberg cell necessary for the diagnosis of Hodgkin's Disease. The background cells are a mixture of lymphocytes, plasma cells, eosinophils, and histiocytes (the "immunoreactive background") and are not part of the malignant proliferation. |
 |
10 |
Case 4 |
Micro |
Hodgkin's Disease, high power of another Reed-Sternberg cell. |
 |
11 |
Case 5 |
Micro |
Burkitt's Lymphoma, low pwer of lymph node with Burkitt's lymphoma showing the characteristic "starry sky" appearance. The "stars" are due to large histiocytes and the malignant cells are the lymphocytes. |
 |
12 |
Case 5 |
Micro |
Acute Lymphoblastic Leukemia-L3/Burkitt's lymphoma: High power of bone marrow aspirate showing the large lymphoid blasts of ALL-L3 or Burkitt's Lymphoma with high nuclear to cytoplasmic ratio, dark-blue cytoplasm, and small lipid-containing vacuoles in the cytoplasm and over the nucleus. ALL-L3 and Burkitt's are the same disease, both are highgrade B cell malignancies. |
 |
13 |
Case 6 |
Micro |
Chronic Lymphocytic Leukemia, low power of peripheral blood smear showing a markedly increased and monomorphic white blood cell population. |
 |
14 |
Case 6 |
Micro |
Chronic Lymphocytic Leukemia, high power of peripheral blood smear showing numerous small lymphocytes which are morphologically normal, but represent a low-grade B cell malignancy. CLL and Small lymphocytic lymphoma represent the same disease with perhaps different clinical symptoms, e.g., peripheral blood lymphocytosis vs lymph node involvement, respectively. |
 |
15 |
Case 7 |
Micro |
Chronic Myelogenous Leukemia, low power of peripheral blood smear showing a markedly increased white blood cell count. |
 |
16 |
Case 7 |
Micro |
Chronic Myelogenous Leukemia, high power of peripheral blood smear showing numerous granulocytes of varying types and stages of development including both mature and immature cells. Other fields would show basophils, which would help with differentiating this from a granulocytic response to infection. |
 |
17 |
Case 8 |
Micro |
Chronic Myelogenous Leukemia, low power of bone marrow core biopsy showing a "packed Marrow", i.e., a very hypercellular marrow as seen in several different types of hematologic malignancies. |