Pathology Review Carousel
FEMALE REPRODUCTIVE I

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Slide #

Tissue

Mag

Feature

	1	Uterus	Gross	Multiple leiomyomas (leiomyomata)
	2	Uterus	Gross	Multiple leiomyomas (leiomyomata). Cut section to show location subserosally, submucosally, and Intramurally. Note: white to tan whorled pattern.
	3	Uterus	LP	Leiomyoma. Junction of leiomyoma and surrounding myometrium. Note: fascicles.
	4	Uterus	MP	Leiomyoma. Fascicles of uniform, fusiform, smooth muscle cells in longitudinal and cross sections.
	5	Uterus	HP	Same as 4. Also note lack of mitoses.
	6	Uterus	MP	Leiomyoma. Area of hyaline fibrosis, a common degenerative change.
	7	Vulva	Gross	Vulva intraepithelial neoplasia. May be papules or macules which can be gray, white, red or darkly pigmented and may be scaly. (Here erythroplakia and leukoplakia, red and white areas). It would be impossible grossly to exclude invasive carcinoma.
	8	Vulva	LP	Vulvar intraepithelial neoplasm III (VIN III). Note: the epithelium appears bluer than normal because of the closely spaced nuclei (increased nuclear to cytoplasmic ratio).
	9	Vulva	HP	VIN III. Crowded cells with high nuclear to cytoplasmic ratios, hyperchromatic, pleomorphic nuclei and increased number of mitoses (with abnormal forms) extending up more than 2/3 of the thickness of the epithelium. No invasion.
	10	Vulva	HP	VIN III. Same as 9. Also, note: parakeratosis and hyperkeratosis.
	11	Uterine Cervix	Gross	Squamous carcinoma.
	12	Uterine Cervix (opened)	Gross	Squamous carcinoma.
	13	Uterine Cervix	LP	Squamous carcinoma. Note: invasive fingers and nests or sheets of cohesive cells.
	14	Uterine Cervix	LP	Squamous carcinoma with adjacent dysplastic epithelium.
	15	Uterine Cervix	MP	Squamous carcinoma. Nests of cohesive cells containing hyperchromatic nuclei and havingan increased nuclear to cytoplasmic ratio. Note: reactive stroma indicating invasion.
	16	Uterine Cervix	HP	Squamous carcinoma. Polygonal cells with central nuclei forming pavement-like sheets and nests. Marked eosinophilia of cytoplasm of some cells indicates keratinization and intercellular bridges are also evident in some areas. (Spaces in tumor are from degeneration and are not gland spaces).
	17	Uterine Cervix	MP	Cervical intraepithelial neoplasia (CIN III) with extension into endocervical glands. (Same epithelial changes as seen in VIN III). CIN is a disease of the metaplastic squamous epithelium of the transformation zone.
	18	Uterus	Gross	Endometrial adenocarcinoma. Note: shaggy, tan, and hemorrhagic appearance.
	19	Uterus	Gross	Endometrial adenocarcinoma. Note: shaggy, glistening and focally hemorrhagic appearance.
	20	Uterus	LP	Endometrioid adenocarcinoma. Note: complexity of glands and extension into myometrium (pale eosinophilic bands).
	21	Uterus	MP	Endometrioid adenocarcinoma. Invasive tumor (note: surrounding smooth muscle) composed of complex glands lined by cuboidal or columnar cells with multilayering and intraluminal tufting.
	22	Uterus	HP	Same as 21.