For more information see: http://www.hlda8.org/CD1toCD350.htm

HUMAN CD Antigen designations (as of Workshop VI )
CD antigen	Cellular expression	Molecular weight	Functions	Other names	Family relationships
CD1a CD1b CD1c CD1d	Cortical thymocytes, Langerhans cells, Dendritic cells, B cells (CD1c), Intestinal epithelium (CD1d)	43-49	MHC class I-like molecule, associated with b2-microglobulin. May have specialised role in antigen presentation		Ig superfamily (IgSF)
CD2	T cells, thymocytes, NK cells	45-58	Adhesion molecule, binding CD58 (LFA-3). Can activate T cells	T11, LFA-2	IgSF
CD2R	Activated T cells	45-58	activation-dependent conformational form of CD2	T11-3	IgSF
CD3	Thymocytes, T cells	g:25-28 d:20 e:20 z:16 h:22	Associated with the T cell antigen receptor. Required for cell surface expression of and signal transduction by TCR.	T3	IgSF (gde) z/h related to FcR g chain
CD4	Thymocyte subsets, helper and inflammatory T cells (about two thirds of peripheral T cells), monocytes, macrophages	55	Coreceptor for MHC class II molecules. Binds lck on cytoplasmic face of membrane. Receptor for HIV-I and HIV-2 gp120.	T4, L3T4	IgSF
CD5	Thymocytes, T cells, subset of B cells	67	Binds to CD72	T1, Ly1	Scavenger receptor
CD6	Thymocytes, T cells, B cell CLL	100-130	unknown.	T12	Scavenger receptor
CD7	Pluripotential hematopoietic cells, thymocytes, T cells	40	unknown. Marker for T cell ALL and pluripotential stem cell leukemias		IgSF
CD8	Thymocyte subsets, cytotoxic T cells (about one third of peripheral T cells)	a: 32-34 b: 32-34	Coreceptor for MHC class I molecules. Binds lck on cytoplasmic face of membrane	T8, Lyt2,3	IgSF
CD9	Pre-B cells, eosinophils, basophils, platelets	22-27	possible role in platelet aggregation and activation		tetraspanning membrane protein
CD10	B and T cell precursors, bone marrow stromal cells	100	zinc metalloproteinase, marker for pre B ALL	Neutral endopeptidase, Common Acute Lymphocytic Leukemia Antigen (CALLA)
CD11a	lymphocytes, granulocytes, monocytes and macrophages	180	aL subunit of integrin LFA-1 (associated with CD18) ; binds to CD54 (ICAM-1), ICAM-2 and ICAM-3	LFA-1
CD11b	myeloid and natural killer cells	170	aM subunit of integrin CR3 (associated with CD18) ; binds CD54, complement component iC3b and extracellular matrix proteins	Mac-1
CD11c	myeloid cells	150	aX subunit of integrin CR4 (associated with CD18) ; binds fibrinogen	CR4, p150, 95
CDw12	monocytes, granulocytes, platelets	90-120	unknown
CD13	myelomonocytic cells	150-170	zinc metalloproteinase	aminopeptidase N
CD14	myelomonocytic cells	53-55	receptor for complex of LPS and LPS binding protein (LBP)
CD15 & CD15S	neutrophils, eosinophils, monocytes		branched pentasaccharide, expressed on glycolipids and many cell surface glycoproteins; the sialylated form is a ligand for CD62E (ELAM)	Lewsi-x (Lex)
CD15u	sulphated CD15
CD16 a & b	neutrophils, NK cells, macrophages	50-80	component of low affinity Fc receptor, FcgRIII, mediates phagocytosis and ADCC.	FcgRIII	IgSF
CDw17	neutrophils, monocytes, platelets		lactosyl ceramide, a cell surface glycosphingolipid
CD18	Leukocytes	95	integrin b2 subunit, associates with CD11a,b and c.
CD19	B cells	95	forms complex with CD21 (CR2)and CD81 (TAPA-1); coreceptor for B cells		IgSF
CD20	B cells	33-37	possible role in regulating B cell activation		tetraspanning membrane protein
CD21	mature B cells, FDC	145	receptor for complement component C3d, EBV. With CD19 and CD81 forms coreceptor for B cells	CR2	complement control protein (CCP) superfamily
CD22	mature B cells	a: 130 b: 140	Adhesion of B cells to monocytes, T cells	BL-CAM	IgSF
CD23	mature B cells, activated macrophages, eosinophils, follicular dendritic cells, platelets	45	low affinity receptor for IgE, ligand for CD19:CD21:CD81 coreceptor	FceRII	C-type lectin
CD24	B cells, granulocytes	35-45	unknown	possible human homologue of mouse Heat Stable Antigen (HSA) or J11d.
CD25	activated T cells, B cells, monocytes	a:55 :b75	IL-2 receptor	Tac	a:CCP b: cytokine receptor superfamily
CD26	Activated B and T cells, macrophages	110	protease. Recently implicated in HIV entry into cells.	Dipeptidyl peptidase IV
CD27	Medullary thymocytes, T cells	50-55	unknown		NGF receptor superfamily
CD28	T cell subsets, activated B cells	44	Activation of naive T cells, receptor for costimulatory signal (signal 2) binds CD80 (B7-1) and B7-2	Tp44	IgSF
CD29	Leukocytes	130	Integrin b1 subunit, associates with CD49a in VLA-1 integrin
CD30	Activated B and T cells	105-120	unknown	Ki-1	NGF receptor superfamily
CD31	monocytes, platelets, granulocytes, B cells, endothelial cells	130-140	Possibly an adhesion molecule	PECAM-1	IgSF
CDw32	Monocytes, granulocytes, B cells eosinophils	40	low affinity Fc receptor for aggregated Ig/immune complexes	FcgRII	IgSF
CD33	myeloid progenitor cells, monocytes	67	unknown		IgSF
CD34	hematopoietic precursors, capillary endothelium	105-120	Ligand for CD62 (L-selectin)
CD35	Erythrocytes, B cells, monocytes, neutrophils, eosinophils, FDC	250	Complement receptor 1, binds C3B and C4b, mediates phagocytosis	CR1	CCP superfamily
CD36	platelets, monocytes	88	unknown	platelet GPIV
CD37	mature B cells, mature T cells, myeloid cells	40-52	unknown		tetraspanning membrane protein
CD38	early B and T cells, activated T cells, germinal centre B cells, plasma cells	45	unknown
CD39	activated B cells, activated NK cells, macrophages, dendritic cells	78	unknown, may mediate adhesion of B cells
CD40	B cells, monocytes, dendritic cells	50	receptor for costimulatory signal for B cells, binds CD40 Ligand (T-BAM),		NGF receptor superfamily
CD40L (CD154)	activated CD4 T cells	39	ligand for CD40,	T-BAM	TNF-like
CD41	platelets, megakaryocytes	125/22 dimer	aIIb integrin, associates with CD61 to form GPIIb, binds fibrinogen, fibronectin, von Willebrand factor and thrombospondin
CD42a       ,  b,          c, d	platelets, megakaryocytes	a: 23 b: 135, 23 c: 22 d: 85	binds von Willebrand factor, thrombin; essential for platelet adhesion at sites of injury	a: GPIX b: GPIba c: GPIbb d: GPV
CD43	leukocytes, except resting B cells	115-135 (neutrophils) 95-115 (T cells)	binds CD54 (ICAM-1)	leukosialin, sialophorin
CD44	leukocytes, erythrocytes	80-95	binds hyaluronic acid, mediates adhesion of leukocytes	Hermes antigen, Pgp-1
CD45	leukocytes	180-240	tyrosine phosphatase, augments signalling through antigen receptor of B and T cells, multiple isoforms result from alternative splicing (see below)	Leukocyte common antigen (LCA), T200, B220
CD45RO	T cell subsets, B cell subsets, monocytes, macrophages	180	isoform of CD45 containing none of the A, B and C exons
CD45RA	B cells, T cell subsets (naive T cells) monocytes	205-220	isoforms of CD45 containing the A exon
CD45RB	T cell subsets, B cells, monocytes, macrophages, granulocytes	190-220	isoforms of CD45 containing the B exon	T200
CD45RC	Restricted T200
CD46	hematopoietic and non-hematopoietic nucleated cells	56/66 (splice variants)	membrane cofactor protein, binds to C3b and C4b to permit their degradation by Factor I	MCP	CCP superfamily
CD47	all cells	47-52	unknown, associated with Rh blood group
CD47R	previously CDw149
CD48	leukocytes	40-47	unknown	Blast-1	IgSF
CD49a	activated T cells, monocytes	210	a1 integrin, associates with CD29, binds collagen, laminin	VLA-1
CD49b	B cells, monocyte, platelets	165	a2 integrin, associates with CD29, binds collagen, laminin	VLA-2
CD49c	B cells	125	a3 integrin, associates with CD29, bindslaminin, fibronectin	VLA-3
CD49d	B cells, thymocytes	150	a4 integrin, associates with CD29, binds fibronectin, PeyerÕs Patch HEV, VCAM-1	VLA-4
CD49e	memory T cells, monocytes, platelets	135, 25 dimer	a5 integrin, associates with CD29, binds fibronectin	VLA-5
CD49f	memory T cells, thymocytes, monocytes	120, 25 dimer	a6integrin, associates with CD29, binds laminin	VLA-6
CD50	thymocytes, T cells, B cells,monocytes, granulocytes	130	unknown	ICAM3
CD51	platelets, megakaryocytes	125,24 dimer	av integrin, associates with CD61, binds vitronectin, von Willebrand factor, fibrinogen and thrombospondin	vitronectin receptor
CD52	thymocytes, T cells, B cells (not plasma cells), monocytes, granulocytes	21-28	unknown, target for antibodies used therapeutically to deplete T cells	CAMPATH-1
CD53	leukocytes	35-42	unknown	MRC OX44	tetraspanning membrane protein
CD54	hematopoietic and non-hematopoietic cells	85-110	InterCellular Adhesion Molecule, (ICAM)-1 binds CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) integrins, receptor for rhinovirus	ICAM-1	IgSF
CD55	hematopoietic and non-hematopoietic cells	60-70	Decay Accelerating Factor (DAF), binds C3b, disassembles C3/C5 convertase	DAF	CCP superfamily
CD56	NK cells	175-185	isoform of Neural Cell Adhesion Molecule (NCAM), adhesion molecule	NKH-1	IgSF
CD57	NK cells subsets of T cells, B cells and monocytes		oligosaccharide, found on many cell surface glycoproteins	HNK-1, Leu-7
CD58	hematopoietic and non-hematopoietic cells	55-70	Leukocyte Function-associated Antigen-3 (LFA-3), binds CD2, adhesion molecule	LFA-3	IgSF
CD59	hematopoietic and non-hematopoietic cells	19	binds comlement components C8 and C9, blocks assembly of membrane attack complex	Protectin, Mac inhibitor
CD60	T cell subsets, platelets, monocytes		oligosaccharide present on gangliosides
CD60a	GD3
CD60b	9-O-acetyl-GD3
CD60c	7-O-acetyl-GD3
CD61	platelets, megakaryocytes, macrophages	105	integrin b3 subunit, associates with CD41 (GPIIb/IIIa) or CD51 (vitronectin receptor)
CD62E	endothelium	140	endothelium leukocyte adhesion molecule (ELAM), bindssialyl-Lewis x, mediates rolling interaction of neutrophils on endothelium	ELAM-1, E-selectin	C type lectin
CD62L	B cells, T cells, monocytes, NK cells	150	leukocyte adhesion molecule (LAM), binds CD34, GlyCAM, mediates rolling interactions with endothelium	LAM-1, L-selectin, LECAM-1	C type lectin
CD62P	platelets, megakaryocytes, endothelium	140	adhesion molecule, binds sialyl Lewis x, mediates interaction of platelets with neutrophils, monocytes and rolling interaction of neutrophils on endothelium	P-selectin, PADGEM	C type lectin
CD63	activated platelets, monocytes, macrophages	53	unknown, is lysosomal membrane protein translocated to cell surface after activation		tetraspanning membrane protein
CD64	monocytes, macrophages	72	hign affinity receptor for IgG	FcgRI	IgSF
	myeloid cells		oligosaccharide component of a ceramide dodecasaccharide
CD65	Ceramide dodecasaccharide 4c
CD66a	neutrophils	160-180	unknown, member of carcinoembryonic antigen (CEA) family (see below)	biliary glycoprotein-1 (BGP-1)	IgSF
CD66b	granulocytes	95-100	unknown, member of carcinoembryonic antigen (CEA) family	previously CD67	IgSF
CD66c	neutrophils, colon carcinoma	90	unknown, member of carcinoembryonic antigen (CEA) family	Nonspecific Crossreacting Antigen (NCA)	IgSF
CD66d	neutrophils	30	unknown, member of carcinoembryonic antigen (CEA) family		IgSF
CD66e	adult colon epithelium, colon carcinoma	180-200	unknown, member of carcinoembryonic antigen (CEA) family	CarcinoEmbryonic Antigen (CEA)	IgSF
CD66f	Pregnancy specific glycoprotein
CD68	monocytes, macrophages, neutrophils, basophils, large lymphocytes	110	unknown	macrosialin
CD69	activated B cells, activated T cells, activated macrophages, activated NK cells	28, 32 homodimer	unknown, early activation antigen	Activation Inducer Molecule (AIM)
CD70	activated B cells, activated T cells, macrophages	75,95,170	unknown	Ki-24
CD71	activated leukocytes	90-95 homodimer	transferrin receptor	T9
CD72	B cells	42 homodimer	unknown, ligand for CD5	Lyb-2	C type lectin
CD73	B cell subsets, T cell subsets	69	ecto-5Õ-nucleotidase, dephosphorylates nucleotides to allow nucleoside uptake
CD74	B cells, macrophages, monocytes, MHC class II positive cells	33,35,41,43 (alternate initiation and splicing)	MHC class II associated Invariant chain	Ii, Ig
CD75	mature B cells, T cell subsets		unknown, possibly oligosaccharide, dependent on sialylation
CDw76 CD75s	alpha-2,6-sialylated lactosamines		unknown, possibly oligosaccharide, dependent on sialylation
CD77	germinal center B cells		unknown,	Globotriaocylceramide (Gb3), Pk blood group
CDw78 (deleted)	B cells		unknown	Ba
CD79a,